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Demarcating the Development of Cirrhosis and Its Complications via Plasma Proteomic Features in an Asymptomatic Population

18 Jun 2025

Abstract excerpt

The early detection of liver cirrhosis and its complications is a conundrum in clinical practice. We aim to address this conundrum using proteomic features of plasma. A total of 52,891 participants without cirrhosis or its complications were recruited from the UK Biobank longitudinal population cohort. We identified GDF15, CDCP1, ADGRG1, GGT1, HGF, MFAP4, and THBS2 from 2923 plasma proteins and developed...

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PMID: 40528431
DOI: 10.1021/acs.jproteome.5c00190

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