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Article

The impact of genetic and environmental risk factors on adverse liver outcomes.

International journal of cancer - 1 May 2026

Zhang Xinyuan, Zhao Longgang, Campbell Peter T, Chen Yun, Fang Aiping, Liu Zhenqiu, Li Xue, Yang Wanshui, Fan Jiangao, Petrick Jessica L, McGlynn Katherine A, Lai Michelle, Zhang Xuehong

Abstract excerpt

To what extent environmental factors are associated with liver diseases and liver cancer among individuals with varying levels of genetic predisposition remains unknown. In 353,703 UK Biobank participants, a validated polygenic risk score (PRS) for liver steatosis (PNPLA3, TM6SF2, MBOAT7, GCKR, and HSD17B13 variants) and an environmental risk score (ERS) from six known risk factors (obesity, type 2 diabetes...

Topics

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Alcohol Drinking
Fatty Liver
Gene-Environment Interaction
Liver Cirrhosis
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41345374
DOI: 10.1002/ijc.70259

Genes

GCKR
HSD17B13
MBOAT7
PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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