A Polygenic Risk Score to Refine Risk Stratification and Prediction for Severe Liver Disease by Clinical Fibrosis Scores

Abstract excerpt

Background & Aims A polygenic risk score based on well-known genetic variants in PNPLA3 , TM6SF2 , MBOAT7 , and GCKR predicts hepatic fat content (polygenic risk score-hepatic fat content [PRS-HFC]). Here, we hypothesized that the addition of PRS-HFC to clinical fibrosis scores may improve risk stratification and prediction of severe liver disease (SLD). Methods We used data from 266,687 individuals in the UK...