Article

Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways

2025-09-18

Abstract excerpt

Cirrhosis and hepatocellular carcinoma (HCC) are long-term complications of chronic liver disease (CLD). In this large multi-ancestry genome-wide association study of all-cause cirrhosis (35,481 cases, 2.36M controls) and HCC (6,680 cases, 1.76M controls), we identified 27 loci associated with cirrhosis (10 novel) and 11 with HCC (three novel). Three novel cirrhosis loci were replicated in independent cohorts (e.g...

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Literature Corpus work: 09dcc5ef-2bc6-59fe-9dc6-834cefbf4742
DOI: 10.1101/2025.09.16.25335186

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