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Article

Association of Genetic Variation With Cirrhosis: A Multi-Trait Genome-Wide Association and Gene-Environment Interaction Study.

Gastroenterology - 1 Apr 2021

Emdin Connor A, Haas Mary, Ajmera Veeral, Simon Tracey G, Homburger Julian, Neben Cynthia, Jiang Lan, Wei Wei-Qi, Feng Qiping, Zhou Alicia, Denny Joshua, Corey Kathleen, Loomba Rohit, Kathiresan Sekar, Khera Amit V

Abstract excerpt

BACKGROUND & AIMS: In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to test whether such variants, aggregated into a polygenic score, enable genomic risk stratification, and to test whether alcohol intake or body mass index interacts with polygenic predisposition. METHODS: We...

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Identifiers

PMID: 33310085
DOI: 10.1053/j.gastro.2020.12.011
PMCID: PMC8035329

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