A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.

doi:10.1097/HC9.0000000000000431

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Article

A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.

Hepatology communications - 1 Jun 2024

Schwantes-An Tae-Hwi, Whitfield John B, Aithal Guruprasad P, Atkinson Stephen R, Bataller Ramon, Botwin Greg, Chalasani Naga P, Cordell Heather J, Daly Ann K, Darlay Rebecca, Day Christopher P, Eyer Florian, Foroud Tatiana, Gawrieh Samer, Gleeson Dermot, Goldman David, Haber Paul S, Jacquet Jean-Marc, Lammert Craig S, Liang Tiebing, Liangpunsakul Suthat, Masson Steven, Mathurin Philippe, Moirand Romain, McQuillin Andrew, Moreno Christophe, Morgan Marsha Y, Mueller Sebastian, Müllhaupt Beat, Nagy Laura E, Nahon Pierre, Nalpas Bertrand, Naveau Sylvie, Perney Pascal, Pirmohamed Munir, Seitz Helmut K, Soyka Michael, Stickel Felix, Thompson Andrew, Thursz Mark R, Trépo Eric, Morgan Timothy R, Seth Devanshi

Abstract excerpt

BACKGROUND: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing single-nucleotide polymorphisms among patients with alcohol-associated cirrhosis (ALC) versus drinkers who did not have evidence of liver fibrosis/cirrhosis. METHODS: Using a...

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Identifiers

PMID: 38727677
DOI: 10.1097/HC9.0000000000000431
PMCID: PMC11093576

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Source receipt: pubmed, retrieved 7 Sept 2026.

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