Article
Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.
Nature genetics - 1 May 2024
Ghouse Jonas, Sveinbjörnsson Gardar, Vujkovic Marijana, Seidelin Anne-Sofie, Gellert-Kristensen Helene, Ahlberg Gustav, Tragante Vinicius, Rand Søren A, Brancale Joseph, Vilarinho Silvia, Lundegaard Pia Rengtved, Sørensen Erik, Erikstrup Christian, Bruun Mie Topholm, Jensen Bitten Aagaard, Brunak Søren, Banasik Karina, Ullum Henrik, Verweij Niek, Lotta Luca, Baras Aris, Mirshahi Tooraj, Carey David J, Kaplan David E, Lynch Julie, Morgan Timothy, Schwantes-An Tae-Hwi, Dochtermann Daniel R, Pyarajan Saiju, Tsao Philip S, Laisk Triin, Mägi Reedik, Kozlitina Julia, Tybjærg-Hansen Anne, Jones David, Knowlton Kirk U, Nadauld Lincoln, Ferkingstad Egil, Björnsson Einar S, Ulfarsson Magnus O, Sturluson Árni, Sulem Patrick, Pedersen Ole B, Ostrowski Sisse R, Gudbjartsson Daniel F, Stefansson Kari, Olesen Morten Salling, Chang Kyong-Mi, Holm Hilma, Bundgaard Henning, Stender Stefan
Abstract excerpt
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk...
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