Article
Connectivity in eQTL networks dictates reproducibility and genomic properties.
Cell reports methods - 23 May 2022
Gaynor Sheila M, Fagny Maud, Lin Xihong, Platig John, Quackenbush John
Abstract excerpt
Expression quantitative trait locus (eQTL) analysis associates SNPs with gene expression; these relationships can be represented as a bipartite network with association strength as "edge weights" between SNPs and genes. However, most eQTL networks use binary edge weights based on thresholded FDR estimates: definitions that influence reproducibility and downstream analyses. We constructed twenty-nine...
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