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Article

Identification of immune cell type-specific susceptibility genes in multiple cancers using transcriptome-wide association studies.

Journal of the National Cancer Institute - 1 Sept 2026

Qin Fei, Hua Xing, Wang Xiaoyu, Zhang Haoyu, Choi Jiyeon, Yang Xiaohong R, Zhang Tongwu, Machiela Mitchell J, Anyaso-Samuel Samuel, Landi Maria Teresa, Berndt Sonja I, Purdue Mark P, Albanes Demetrius, Zhu Bin, Brown Kevin M, Shi Jianxin, Yu Kai

Abstract excerpt

BACKGROUND: Transcriptome-wide association studies (TWAS) integrate gene expression and genome-wide association studies (GWAS) to identify disease susceptibility genes. Because gene expression varies substantially across cell types within tissues, cell type-specific prediction models may enhance the power of TWAS. METHODS: We conducted cell type-specific TWAS leveraging single-cell RNA sequencing data from the...

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Topics

Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcriptome

Male

Female

Gene Expression Profiling

Single-Cell Gene Expression Analysis

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41967136
DOI: 10.1093/jnci/djag108
PMCID: PMC13277145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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