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Article

Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers.

American journal of human genetics - 5 Sept 2019

Chen Zhishan, Wen Wanqing, Beeghly-Fadiel Alicia, Shu Xiao-Ou, Díez-Obrero Virginia, Long Jirong, Bao Jiandong, Wang Jing, Liu Qi, Cai Qiuyin, Moreno Victor, Zheng Wei, Guo Xingyi

Abstract excerpt

Genome-wide association studies (GWASs) have identified hundreds of genetic risk variants for human cancers. However, target genes for the majority of risk loci remain largely unexplored. It is also unclear whether GWAS risk-loci-associated genes contribute to mutational signatures and tumor mutational burden (TMB) in cancer tissues. We systematically conducted cis-expression quantitative trait loci (cis-eQTL)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31402092
DOI: 10.1016/j.ajhg.2019.07.006
PMCID: PMC6731359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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