Article
Exploring regulation in tissues with eQTL networks.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2017
Fagny Maud, Paulson Joseph N, Kuijjer Marieke L, Sonawane Abhijeet R, Chen Cho-Yi, Lopes-Ramos Camila M, Glass Kimberly, Quackenbush John, Platig John
Abstract excerpt
Characterizing the collective regulatory impact of genetic variants on complex phenotypes is a major challenge in developing a genotype to phenotype map. Using expression quantitative trait locus (eQTL) analyses, we constructed bipartite networks in which edges represent significant associations between genetic variants and gene expression levels and found that the network structure informs regulatory function....
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