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Article

Polygenic risk scores and plasma proteomics identify cancer-related proteins and trans-regulated protein networks.

Cell genomics - 9 Sept 2026

Dutta Diptavo, Zhang Jingning, Guo Xinyu, Quint Rosamund, Rooney Mary R, Machiela Mitchell J, Brown Kevin M, Coresh Josef, Battle Alexis J, Platz Elizabeth A, Chatterjee Nilanjan

Abstract excerpt

Genome-wide association studies identify cancer susceptibility loci, but downstream protein mechanisms remain incompletely defined. We integrate polygenic risk scores (PRSs) for 21 cancers with 4,955 plasma proteins measured in cancer-free Atherosclerosis Risk in Communities (ARIC) participants to prioritize cancer-related proteins and protein networks. The protein quantitative trait score (pQTS) approach...

Read the complete abstract on PubMed

Topics

Humans
Genetic Risk Score
Proteomics
Neoplasms
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Protein Interaction Maps

Multifactorial Inheritance

Blood Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42567164
DOI: 10.1016/j.xgen.2026.101322
PMCID: PMC13576709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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