Article

Leveraging and partitioning polygenic risk scores to identify cancer-related proteins

2025-11-25

Abstract excerpt

<h4>Background</h4> Large-scale genome-wide association studies (GWAS) have identified numerous common susceptibility variants associated with various cancers but underlying molecular mechanisms remain largely unknown. <h4>Methods</h4> Here we investigated the associations of susceptibility SNPs from 21 cancers with 4,955 plasma protein levels measured in cancer-free participants (N=8,664) from the Atheroscleros...

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Literature Corpus work: 3a087957-29ce-5ace-9997-ca44538b4e13
DOI: 10.1101/2025.11.23.25340827

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