Article
Genetic landscape of adult Langerhans cell histiocytosis with lung involvement.
The European respiratory journal - 1 Feb 2020
Jouenne Fanélie, Chevret Sylvie, Bugnet Emmanuelle, Clappier Emmanuelle, Lorillon Gwenaël, Meignin Véronique, Sadoux Aurélie, Cohen Shannon, Haziot Alain, How-Kit Alexandre, Kannengiesser Caroline, Lebbé Céleste, Gossot Dominique, Mourah Samia, Tazi Abdellatif
Abstract excerpt
The clinical significance of the BRAF V600E mutation in adult Langerhans cell histiocytosis (LCH), including pulmonary Langerhans cell histiocytosis (PLCH), is not well understood. Similarly, the spectrum of molecular alterations involved in adult LCH has not been fully delineated. To address these issues, we genotyped a large number of adult LCH biopsies and searched for an association of identified molecular...
Topics
- Adult
- Child
- Female
- High-Throughput Nucleotide Sequencing
- Histiocytosis, Langerhans-Cell
- Humans
- Lung
- Mutation
- Proto-Oncogene Proteins B-raf