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Article

BRAF Deletion in Adult Patients with Langerhans Cell Histiocytosis Correlates with Multisystem Disease and Poor Outcomes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 6 Jan 2025

Lang Min, Chang Long, Cai Hao, Lin He, Liu Zheng-Zheng, Duan Ming-Hui, Zhou Dao-Bin, Cao Xin-Xin

Abstract excerpt

PURPOSE: Langerhans cell histiocytosis (LCH) is a rare and highly heterogeneous histiocytosis. There are currently few studies examining the correlation between molecular profiling and clinical phenotype or outcomes in adult patients with LCH. The objective of this study was to characterize the genomic landscape of adult LCH and correlate molecular findings with clinical features and patient outcomes....

Topics

Humans
Histiocytosis, Langerhans-Cell
Proto-Oncogene Proteins B-raf
Male
Female
Adult
Middle Aged
Aged
Young Adult
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adolescent

High-Throughput Nucleotide Sequencing

Source

Identifiers

PMID: 39513946
DOI: 10.1158/1078-0432.CCR-24-1802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39513946-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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