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Genetic Landscape and Its Prognostic Impact in Children With Langerhans Cell Histiocytosis

15 May 2024

Abstract excerpt

CONTEXT.—: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that predominantly affects young children. OBJECTIVE.—: To investigate genetic alterations and their correlation with clinical characteristics and prognosis in pediatric LCH. DESIGN.—: We performed targeted sequencing to detect mutations in LCH lesions from pediatric patients. RESULTS.—: A total of 30 genomic alterations in 5 genes of the...

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PMID: 38749502
DOI: 10.5858/arpa.2023-0236-oa

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