Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study.

doi:10.1182/bloodadvances.2022007947

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Article

Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study.

Blood advances - 28 Feb 2023

Kemps Paul G, Zondag Timo C E, Arnardóttir Helga B, Solleveld-Westerink Nienke, Borst Jelske, Steenwijk Eline C, van Egmond Demi, Swennenhuis Joost F, Stelloo Ellen, Trambusti Irene, Verdijk Robert M, van Noesel Carel J M, Cleven Arjen H G, Scheijde-Vermeulen Marijn A, Koudijs Marco J, Krsková Lenka, Hawkins Cynthia, Egeler R Maarten, Brok Jesper, von Bahr Greenwood Tatiana, Svojgr Karel, Beishuizen Auke, van Laar Jan A M, Pötschger Ulrike, Hutter Caroline, Sieni Elena, Minkov Milen, Abla Oussama, van Wezel Tom, van den Bos Cor, van Halteren Astrid G S

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic alterations in hematopoietic precursor cells differentiating into CD1a+/CD207+ histiocytes. LCH clinical manifestation is highly heterogeneous. BRAF and MAP2K1 mutations account for ∼80% of genetic driver...

Topics

Humans
Cohort Studies
Proto-Oncogene Proteins B-raf
Histiocytosis, Langerhans-Cell
Mutation
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36083130
DOI: 10.1182/bloodadvances.2022007947
PMCID: PMC9979766

Genes

BRAF
MAP2K1
ARAF
CD207
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-36083130-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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