Article
Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study.
Blood advances - 28 Feb 2023
Kemps Paul G, Zondag Timo C E, Arnardóttir Helga B, Solleveld-Westerink Nienke, Borst Jelske, Steenwijk Eline C, van Egmond Demi, Swennenhuis Joost F, Stelloo Ellen, Trambusti Irene, Verdijk Robert M, van Noesel Carel J M, Cleven Arjen H G, Scheijde-Vermeulen Marijn A, Koudijs Marco J, Krsková Lenka, Hawkins Cynthia, Egeler R Maarten, Brok Jesper, von Bahr Greenwood Tatiana, Svojgr Karel, Beishuizen Auke, van Laar Jan A M, Pötschger Ulrike, Hutter Caroline, Sieni Elena, Minkov Milen, Abla Oussama, van Wezel Tom, van den Bos Cor, van Halteren Astrid G S
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic alterations in hematopoietic precursor cells differentiating into CD1a+/CD207+ histiocytes. LCH clinical manifestation is highly heterogeneous. BRAF and MAP2K1 mutations account for ∼80% of genetic driver alterations in neoplastic LCH cells. However, their clinical associations remain incompletely understood. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.