Article
Primary pulmonary Langerhans cell histiocytosis: comprehensive clinicopathologic and molecular genetic analysis of 13 cases.
Human pathology - 1 Apr 2026
Zhang Yanping, Liu Enjie, Yang Minglei, Wang Guannan, Zhao Wugan, Li Wencai, Li Shenglei
Abstract excerpt
Primary pulmonary Langerhans cell histiocytosis (PLCH) is a rare entity. To characterize its clinicopathological and molecular features, 13 cases (15 specimens) were retrospectively analyzed, incorporating clinical information, imaging findings, histopathological features, immunohistochemical results, BRAFV600E mutation status, and DNA-based next-generation sequencing data. The patients ranged in age from 17 to...
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