Primary pulmonary Langerhans cell histiocytosis: comprehensive clinicopathologic and molecular genetic analysis of 13 cases.

doi:10.1016/j.humpath.2026.106034

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Article

Primary pulmonary Langerhans cell histiocytosis: comprehensive clinicopathologic and molecular genetic analysis of 13 cases.

Human pathology - 1 Apr 2026

Zhang Yanping, Liu Enjie, Yang Minglei, Wang Guannan, Zhao Wugan, Li Wencai, Li Shenglei

Abstract excerpt

Primary pulmonary Langerhans cell histiocytosis (PLCH) is a rare entity. To characterize its clinicopathological and molecular features, 13 cases (15 specimens) were retrospectively analyzed, incorporating clinical information, imaging findings, histopathological features, immunohistochemical results, BRAFV600E mutation status, and DNA-based next-generation sequencing data. The patients ranged in age from 17 to...

Topics

Humans
Male
Adult
Histiocytosis, Langerhans-Cell
Middle Aged
Adolescent
Female
Young Adult
Proto-Oncogene Proteins B-raf
DNA Mutational Analysis
Retrospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

High-Throughput Nucleotide Sequencing

Mutation

Genetic Predisposition to Disease

Lung Diseases

Phenotype

MAP Kinase Kinase 1

Source

Open in PubMed

Identifiers

PMID: 41539487
DOI: 10.1016/j.humpath.2026.106034

Genes

DUSP4
BRAF
MAP2K1
RRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41539487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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