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Article

Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children.

Cancer medicine - 1 Dec 2024

Tang Xue, Gao Ju, Guo Xia, Wan Zhi, Sun Jing-Jing

Abstract excerpt

BACKGROUND: Langerhans cell histiocytosis (LCH) is the most prevalent histiocytic disorder in pediatric populations, with a highly heterogeneous clinical presentation. Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAFV600E mutation, has not been sufficiently studied. METHODS: This study presented data on 33 pediatric LCH patients treated at our...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39711503
DOI: 10.1002/cam4.70532
PMCID: PMC11664316

Genes

BRAF
MAP2K1
ARAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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