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Article

Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children.

Cancer medicine - 1 Dec 2024

Tang Xue, Gao Ju, Guo Xia, Wan Zhi, Sun Jing-Jing

Abstract excerpt

BACKGROUND: Langerhans cell histiocytosis (LCH) is the most prevalent histiocytic disorder in pediatric populations, with a highly heterogeneous clinical presentation. Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAFV600E mutation...

Topics

Humans
Histiocytosis, Langerhans-Cell
Proto-Oncogene Proteins B-raf
Male
Female
Child
Child, Preschool
Mutation
Infant
Adolescent
Phenotype
MAP Kinase Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39711503
DOI: 10.1002/cam4.70532
PMCID: PMC11664316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-39711503-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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