Article
BRAFV600E mutation in cutaneous lesions of patients with adult Langerhans cell histiocytosis.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Jun 2015
Varga E, Korom I, Polyánka H, Szabó K, Széll M, Baltás E, Bata-Csörgő Zs, Kemény L, Oláh J
Abstract excerpt
BACKGROUND: Langerhans cell histiocytosis (LCH) is characterized by the proliferation of pathologic Langerhans cells. The disease can develop in any age and can affect almost any organ. Cutaneous involvement is frequent in LCH. The recent demonstration of the activating, oncogenic BRAFV600E gene mutation in LCH samples strongly supports the neoplastic origin of the disease. OBJECTIVES: Our aim was to analyse the...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Male
- Middle Aged
- Mutation
- Proto-Oncogene Proteins B-raf