Article
Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.
Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009
Inagawa Takabumi, Yamada-Inagawa Tomoko, Eydmann Trevor, Mian I Saira, Wang Teresa S, Dalgaard Jacob Z
Abstract excerpt
Here, we identify a phylogenetically conserved Schizosaccharomyces pombe factor, named Rtf2, as a key requirement for efficient replication termination at the site-specific replication barrier RTS1. We show that Rtf2, a proliferating cell nuclear antigen-interacting protein, promotes termination at RTS1 by preventing replication restart; in the absence of Rtf2, we observe the establishment of "slow-moving"...
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