Article
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.
Molecular cell - 27 Aug 2010
Fachinetti Daniele, Bermejo Rodrigo, Cocito Andrea, Minardi Simone, Katou Yuki, Kanoh Yutaka, Shirahige Katsuhiko, Azvolinsky Anna, Zakian Virginia A, Foiani Marco
Abstract excerpt
Chromosome replication initiates at multiple replicons and terminates when forks converge. In E. coli, the Tus-TER complex mediates polar fork converging at the terminator region, and aberrant termination events challenge chromosome integrity and segregation. Since in eukaryotes, termination is less characterized, we used budding yeast to identify the factors assisting fork fusion at replicating chromosomes....
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