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Article

NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo.

Molecular reproduction and development - 1 Jan 2020

Ortega M Sofia, Kelleher Andrew M, O'Neil Eleanore, Benne Joshua, Cecil Raissa, Spencer Thomas E

Abstract excerpt

During preimplantation development, the embryo undergoes two consecutive lineages specifications. The first cell fate decision determines which cells give rise to the trophectoderm (TE) and the inner cell mass (ICM). Subsequently, the ICM differentiates into hypoblast and epiblast, the latter giving rise to the embryo proper. The transcription factors that govern these cell fate decisions have been extensively...

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Identifiers

PMID: 31803983
DOI: 10.1002/mrd.23304
PMCID: PMC6983337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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