Article
Base editing in bovine embryos reveals a species-specific role of SOX2 in regulation of pluripotency
2021-11-11
Abstract excerpt
The emergence of the first three lineages during development are orchestrated by a network of transcription factors, which are best characterized in mice. However, the role and regulation of these factors are not completely conserved in other mammals, including human and cattle. Here, we establish a gene inactivation system by introducing premature codon with cytosine base editor in bovine embryos with a robust ef...
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Identifiers and source
- Literature Corpus work
- 906f743f-6315-5d5a-9505-b96c923b3b6e
- DOI
- 10.1101/2021.11.10.468023