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Article

Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.

Developmental biology - 1 Aug 2010

Messerschmidt Daniel M, Kemler Rolf

Abstract excerpt

Early lineage segregation in mouse development results in two, either CDX2- or OCT4/NANOG-positive, cell populations. CDX2-positive cells form the trophectoderm (TE), OCT4/NANOG-positive cells the inner cell mass (ICM). In a second lineage decision ICM cells segregate into Epiblast (EPI) and primitive endoderm (PE). EPI and PE formation depend on the activity of the transcription factors Nanog and Gata4/6. A role...

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Source

Identifiers

PMID: 20435031
DOI: 10.1016/j.ydbio.2010.04.020

Genes

CDX2
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.PMID 20435031Read ↗

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