Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signaling

18 Nov 2024

Abstract excerpt

The human blastocyst contains the pluripotent epiblast from which human embryonic stem cells (hESCs) can be derived. ACTIVIN/NODAL signaling maintains expression of the transcription factor NANOG and in vitro propagation of hESCs. It is unknown whether this reflects a functional requirement for epiblast development in human embryos. Here, we characterized NODAL signaling activity during pre-implantation human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Renal and related cancers
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39561779
DOI: 10.1016/j.devcel.2024.10.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signalingPMID 39561779Read ↗

Activin/Nodal signalling maintains pluripotency by controlling Nanog expressionSemantic proximity Read ↗

Human Naïve Epiblast Cells Possess Unrestricted Lineage PotentialSemantic proximity Read ↗

A <i>Nanog</i> -dependent gene cluster initiates the specification of the pluripotent epiblastSemantic proximity Read ↗

NANOG initiates epiblast fate through the coordination of pluripotency genes expressionSemantic proximity Read ↗

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read ↗

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centreSemantic proximity Read ↗

A Case for Revisiting Nodal Signaling in Human Pluripotent Stem CellsSemantic proximity Read ↗

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinctionSemantic proximity Read ↗

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.Semantic proximity Read ↗

NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo.Semantic proximity Read ↗

Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell StateSemantic proximity Read ↗

Human hypoblast formation is not dependent on FGF signallingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.