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NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction

18 Aug 2025

Abstract excerpt

Abstract Loss of pluripotency is an essential step in post-implantation development that facilitates the emergence of somatic cell identities essential for gastrulation. Before implantation, pluripotent cell identity is governed by a gene regulatory network that includes the key transcription factors SOX2 and NANOG. However, it is unclear how the pluripotency gene regulatory network is dissolved to enable lineage...

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PMID: 40826182
DOI: 10.1038/s44318-025-00527-9

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