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Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation

11 May 2018

Abstract excerpt

POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable roles in early embryo development and cell lineage specification. The role of embryonic POU5F1 in blastocyst formation and cell lineage specification differs between mammalian species but remains completely unknown in cattle. The CRISPR/Cas9 system was utilized for targeted disruption of the POU5F1 gene by direct...

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PMID: 29773834
DOI: 10.1038/s41598-018-25964-x

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