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Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions

13 Nov 2014

Abstract excerpt

The progranulin (PGRN) is known to protect regulatory T cells (Tregs) from a negative regulation by TNF-α, and its levels are elevated in various kinds of autoimmune diseases. Whether PGRN directly regulates the conversion of CD4+CD25-T cells into Foxp3-expressing regulatory T cells (iTreg), and whether PGRN affects the immunosuppressive function of Tregs, however, remain unknown. In this study we provide...

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PMID: 25393765
DOI: 10.1371/journal.pone.0112110

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