Article

SENP2 restrains the generation of pathogenic Th17 cells in inflammatory bowel disease

2022-09-15

Abstract excerpt

<title>Abstract</title> <p>The molecular mechanisms contributing to the regulation of Th17-mediated inflammation remain underexplored. We here report a SUMO-specific protease (SENP)2-mediated pathway induced in pathogenic Th17 cells that restricts the pathogenesis of inflammatory colitis. SENP2 regulates the maturation of small ubiquitin-like modifiers (SUMO) and recycles SUMO from the substrate proteins. We foun...

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Literature Corpus work: 9c23f78b-01cc-5761-ac84-1a37b164c3fd
DOI: 10.21203/rs.3.rs-1989194/v1

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