Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer

4 Dec 2019

Abstract excerpt

TERT promoter mutations occur in the majority of glioblastoma, bladder cancer (BC), and other malignancies while the ETS family transcription factors GABPA and its partner GABPB1 activate the mutant TERT promoter and telomerase in these tumors. GABPA depletion or the disruption of the GABPA/GABPB1 complex by knocking down GABPB1 was shown to inhibit telomerase, thereby eliminating the tumorigenic potential of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31802036
DOI: 10.1038/s41418-019-0466-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancerPMID 31802036Read ↗

TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friendsSemantic proximity Read ↗

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.Semantic proximity Read ↗

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinomaSemantic proximity Read ↗

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer FeaturesSemantic proximity Read ↗

Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.Semantic proximity Read ↗

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.Semantic proximity Read ↗

GABPβ1L Wakes Up TERT.Semantic proximity Read ↗

GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.Semantic proximity Read ↗

The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible.Semantic proximity Read ↗

For a systematic comprehension of GAB2: an analysis based on pan-cancerSemantic proximity Read ↗

Stepwise molecular mechanisms responsible for chemoresistance in bladder cancer cellsSemantic proximity Read ↗

Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.