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Article

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features

8 Mar 2022

Abstract excerpt

Promoter mutations of the telomerase reverse transcriptase (TERT) gene occur frequently in thyroid carcinoma (TC), including papillary (PTC) and anaplastic subtypes (ATC). Given that the ETS family transcription factors GABPA and GABPB1 activate the mutant TERT promoter and induce TERT expression for telomerase activation, GABPB1 has been proposed as a cancer therapeutic target to inhibit telomerase. Here, we...

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PMID: 35326537
DOI: 10.3390/cancers14061385

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