Article
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.
Oncogene - 1 Feb 2019
Yuan Xiaotian, Mu Ninni, Wang Na, Strååt Klas, Sofiadis Anastasios, Guo Yanxia, Stenman Adam, Li Kailin, Cheng Guanghui, Zhang Lu, Kong Feng, Ekblad Lars, Wennerberg Johan, Nilsson Inga-Lena, Juhlin C Christofer, Larsson Catharina, Xu Dawei
Abstract excerpt
The ETS family transcription factor GABPA is suggested as an oncogenic element, which is further supported by the recent reporting of it as the sole ETS member to activate the mutant TERT promoter in thyroid carcinomas (TC). However, it remains unclear how GABPA contributes to TC pathogenesis. The present study is designed to address this issue. TERT expression was significantly diminished in TERT...
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