Article
Oncogenic mutations drive intestinal cancer initiation through paracrine remodeling.
Cancer cell - 12 Jul 2021
Yan Helen H N, Chan April S, Leung Suet Yi
Abstract excerpt
Three articles in Nature show that intestinal stem cells with cancer-promoting mutations could shape the surrounding normal tissue in their favor to promote clonal fixation and field expansion, raising the possibility of developing therapeutic strategies that maintain or enhance the health of normal cells to out-compete the mutant cells.
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