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Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection

31 Aug 2022

Abstract excerpt

Colorectal cancer (CRC) is among the deadliest cancers worldwide, with metastasis being the main cause of patient mortality. During CRC progression the complex tumor ecosystem changes in its composition at virtually every stage. However, clonal dynamics and associated niche-dependencies at these stages are unknown. Hence, it is of importance to utilize models that faithfully recapitulate human CRC to define its...

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PMID: 36077793
DOI: 10.3390/cancers14174260

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