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Article

Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma.

Neuro-oncology - 1 Nov 2016

Nagashima Hiroaki, Tanaka Kazuhiro, Sasayama Takashi, Irino Yasuhiro, Sato Naoko, Takeuchi Yukiko, Kyotani Katsusuke, Mukasa Akitake, Mizukawa Katsu, Sakata Junichi, Yamamoto Yusuke, Hosoda Kohkichi, Itoh Tomoo, Sasaki Ryohei, Kohmura Eiji

Abstract excerpt

BACKGROUND: Mutations in the isocitrate dehydrogenase 1 (IDH1) gene that are frequently observed in low-grade glioma are strongly associated with the accumulation of 2-hydroxyglutarate (2HG), which is a valuable diagnostic and prognostic biomarker of IDH1 mutant glioma. However, conventional MR spectroscopy (MRS)-based noninvasive detection of 2HG is challenging. In this study, we aimed to determine the...

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Identifiers

PMID: 27154922
DOI: 10.1093/neuonc/now090
PMCID: PMC5063515

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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