Article
2-Hydroxyglutarate as an MR spectroscopic predictor of an IDH mutation in gliomas.
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin - 1 Dec 2024
Bauer Jochen, Raum Heiner N, Kugel Harald, Müther Michael, Mannil Manoj, Heindel Walter
Abstract excerpt
The mutated enzyme isocitrate dehydrogenase (IDH) 1 and 2 has been detected in various tumor entities such as gliomas and can convert α-ketoglutarate into the oncometabolite 2-hydroxyglutarate (2-HG). This neuro-oncologically significant metabolic product can be detected by MR spectroscopy and is therefore suitable for noninvasive glioma classification and therapy monitoring.This paper provides an up-to-date...
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