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Article

A map of the altered glioma metabolism.

Trends in molecular medicine - 1 Nov 2021

Deshmukh Ruhi, Allega Maria Francesca, Tardito Saverio

Abstract excerpt

The frequent occurrence of neomorphic isocitrate dehydrogenase 1 (IDH1) mutations in low-grade glioma led to an IDH-centric classification of these tumors. However, exploiting metabolic alterations of glioma for diagnostic imaging and treatment has marginally improved patients' prognosis. Here we discuss the nutritional microenvironment of glioma, shaped by the distinctive dependence of the brain on glucose and...

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Identifiers

PMID: 34489164
DOI: 10.1016/j.molmed.2021.07.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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