Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.

Scientific reports - 21 Nov 2019

Singh Sonal, McDonough Caitrin W, Gong Yan, Bailey Kent R, Boerwinkle Eric, Chapman Arlene B, Gums John G, Turner Stephen T, Cooper-DeHoff Rhonda M, Johnson Julie A

Abstract excerpt

Chlorthalidone (CTD) is more potent than hydrochlorothiazide (HCTZ) in reducing blood pressure (BP) in hypertensive patients, though both are plagued with BP response variability. However, there is a void in the literature regarding the genetic determinants contributing to the variability observed in BP response to CTD. We performed a discovery genome wide association analysis of BP response post CTD treatment in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 2

Share to Diuretics

Share to Genetic Loci

Share to Hypertension

Share to Pharmacogenomic Testing

Share to Pharmacogenomic Variants

Source

Open in PubMed Open full text

Identifiers

PMID: 31754133
DOI: 10.1038/s41598-019-53345-5
PMCID: PMC6872535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.PMID 31754133Read ↗

Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.Semantic proximity Read ↗

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to HydrochlorothiazideSemantic proximity Read ↗

Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.Semantic proximity Read ↗

Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.Semantic proximity Read ↗

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.Semantic proximity Read ↗

Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.Semantic proximity Read ↗

Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study.Semantic proximity Read ↗

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.Semantic proximity Read ↗

Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).Semantic proximity Read ↗

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.Semantic proximity Read ↗

Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini reviewSemantic proximity Read ↗

PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.