Article
Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.
Circulation. Cardiovascular genetics - 1 Jan 2017
Shahin Mohamed H, Sá Ana C, Webb Amy, Gong Yan, Langaee Taimour, McDonough Caitrin W, Riva Alberto, Beitleshees Amber L, Chapman Arlene B, Gums John G, Turner Stephen T, Boerwinkle Eric, Scherer Steven E, Sadee Wolfgang, Cooper-DeHoff Rhonda M, Johnson Julie A
Abstract excerpt
BACKGROUND: Thiazide diuretics are among the most commonly prescribed antihypertensives. However, <50% of thiazide-treated patients achieve blood pressure (BP) control. Herein, we used different omics (genomics and transcriptomics) to identify novel biomarkers of thiazide diuretics BP response. METHODS AND RESULTS: Genome-wide analysis included 228 white hypertensives with BP determined at baseline and after 9...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.