Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.

doi:10.1161/JAHA.117.006522

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Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.

Journal of the American Heart Association - 2 Nov 2017

Magvanjav Oyunbileg, Gong Yan, McDonough Caitrin W, Chapman Arlene B, Turner Stephen T, Gums John G, Bailey Kent R, Boerwinkle Eric, Beitelshees Amber L, Tanaka Toshihiro, Kubo Michiaki, Pepine Carl J, Cooper-DeHoff Rhonda M, Johnson Julie A

Abstract excerpt

BACKGROUND: The majority of hypertensive individuals require combination antihypertensive therapy to achieve adequate blood pressure (BP) control. This study aimed to identify genetic variants associated with uncontrolled BP on combination therapy with a thiazide diuretic and a β-blocker. METHODS AND RESULTS: A genome-wide association study of uncontrolled BP on combination therapy was conducted among 314 white...

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PMID: 29097388
DOI: 10.1161/JAHA.117.006522
PMCID: PMC5721751

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AQP9
LIPC

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