Article
Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
Circulation. Genomic and precision medicine - 1 Apr 2018
McDonough Caitrin W, Magvanjav Oyunbileg, Sá Ana C C, El Rouby Nihal M, Dave Chintan, Deitchman Amelia N, Kawaguchi-Suzuki Marina, Mei Wenbin, Shen Yong, Singh Ravi Shankar Prasad, Solayman Mohamed, Bailey Kent R, Boerwinkle Eric, Chapman Arlene B, Gums John G, Webb Amy, Scherer Steven E, Sadee Wolfgang, Turner Stephen T, Cooper-DeHoff Rhonda M, Gong Yan, Johnson Julie A
Abstract excerpt
BACKGROUND: Plasma renin is an important regulator of blood pressure (BP). Plasma renin activity (PRA) has been shown to correlate with variability in BP response to antihypertensive agents. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with baseline PRA using data from the PEAR study (Pharmacogenomic Evaluation of Antihypertensive Responses). METHODS:...
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