Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.

Journal of internal medicine - 1 Nov 2014

Vandell A G, McDonough C W, Gong Y, Langaee T Y, Lucas A M, Chapman A B, Gums J G, Beitelshees A L, Bailey K R, Johnson R J, Boerwinkle E, Turner S T, Cooper-DeHoff R M, Johnson J A

Abstract excerpt

OBJECTIVE: Elevations in uric acid (UA) and the associated hyperuricaemia are commonly observed secondary to treatment with thiazide diuretics. We sought to identify novel single nucleotide polymorphisms (SNPs) associated with hydrochlorothiazide (HCTZ)-induced elevations in UA and hyperuricaemia. METHODS: A genome-wide association study of HCTZ-induced changes in UA was performed in Caucasian and African...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to White People
Share to Antihypertensive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black or African American

Share to Diuretics

Share to Hydrochlorothiazide

Share to Hypertension

Share to Hyperuricemia

Share to Pharmacogenetics

Source

Open in PubMed Open full text

Identifiers

PMID: 24612202
DOI: 10.1111/joim.12215
PMCID: PMC4130802

Genes

FTO
COX18
PADI4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.PMID 24612202Read ↗

Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.Semantic proximity Read ↗

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.Semantic proximity Read ↗

Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide.Semantic proximity Read ↗

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.Semantic proximity Read ↗

Pharmacogenomics of Hypertension: A Genome‐Wide, Placebo‐Controlled Cross‐Over Study, Using Four Classes of Antihypertensive DrugsSemantic proximity Read ↗

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to HydrochlorothiazideSemantic proximity Read ↗

A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.Semantic proximity Read ↗

The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database AnalysisSemantic proximity Read ↗

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.Semantic proximity Read ↗

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.Semantic proximity Read ↗

The Epidemiology and Genetics of Hyperuricemia and Gout Across Major Racial Groups: A literature Review and Population Genetics Secondary Data AnalysisSemantic proximity Read ↗

Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.