Article
Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study.
Circulation. Cardiovascular genetics - 1 Dec 2012
Gong Yan, McDonough Caitrin W, Wang Zhiying, Hou Wei, Cooper-DeHoff Rhonda M, Langaee Taimour Y, Beitelshees Amber L, Chapman Arlene B, Gums John G, Bailey Kent R, Boerwinkle Eric, Turner Stephen T, Johnson Julie A
Abstract excerpt
BACKGROUND: To date, 39 single nucleotide polymorphisms (SNPs) have been associated with blood pressure (BP) or hypertension in genome-wide association studies in whites. Our hypothesis is that the loci/SNPs associated with BP/hypertension are also associated with BP response to antihypertensive drugs. METHODS AND RESULTS: We assessed the association of these loci with BP response to atenolol or...
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