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Article

Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2008

Turner Stephen T, Bailey Kent R, Fridley Brooke L, Chapman Arlene B, Schwartz Gary L, Chai High Seng, Sicotte Hugues, Kocher Jean-Pierre, Rodin Andréi S, Boerwinkle Eric

Abstract excerpt

We conducted a genome-wide association study to identify novel genes influencing diastolic blood pressure (BP) response to hydrochlorothiazide, a commonly prescribed thiazide diuretic preferred for the treatment of high BP. Affymetrix GeneChip Human Mapping 100K Arrays were used to measure single nucleotide polymorphisms across the 22 autosomes in 194 non-Hispanic black subjects and 195 non-Hispanic white...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18591461
DOI: 10.1161/HYPERTENSIONAHA.107.104273
PMCID: PMC2692710

Genes

LYZ
YEATS4
FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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