Article
Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.
Scientific reports - 22 Nov 2017
Sá Ana Caroline C, Webb Amy, Gong Yan, McDonough Caitrin W, Datta Somnath, Langaee Taimour Y, Turner Stephen T, Beitelshees Amber L, Chapman Arlene B, Boerwinkle Eric, Gums John G, Scherer Steven E, Cooper-DeHoff Rhonda M, Sadee Wolfgang, Johnson Julie A
Abstract excerpt
Thiazide diuretics (TD) are commonly prescribed anti-hypertensives worldwide. However, <40% of patients treated with thiazide monotherapy achieve BP control. This study uses whole transcriptome sequencing to identify novel molecular markers associated with BP response to TD. We assessed global RNA expression levels in whole blood samples from 150 participants, representing patients in the upper and lower quartile...
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