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Article

Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.

Journal of molecular and cellular cardiology - 1 Jan 2020

Yang Bicheng, Huang Yanrui, Zhang Haifeng, Huang Yan, Zhou Huanjiao Jenny, Young Lawrence, Xiao Haipeng, Min Wang

Abstract excerpt

OBJECTIVE: Sick sinus syndrome (SSS) is associated with loss of HCN4 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 4) function in the cardiac conduction system. The underlying mechanism for SSS remains elusive. This study is to investigate how mitochondrial oxidative stress induces HCN4 downregulation associated with in sick sinus syndrome. METHODS AND RESULTS: Trx2lox/lox mice were...

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Source

Identifiers

PMID: 31751569
DOI: 10.1016/j.yjmcc.2019.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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