Article

PITX2C Deficiency Promotes Arrhythmogenic Remodeling via Oxidative Stress in Atrial Myocytes

2026-03-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims</h4> Genome-wide association studies have identified numerous cardiac transcription factors in association with atrial fibrillation. Amongst these transcription factors, the paired-like homeodomain transcription factor 2 ( PITX2 ) is the strongest genetic risk variant associated with atrial fibrillation. However, the downstream mechanisms of PITX2 are not completely understood. Here,...

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Literature Corpus work: f26382bd-352c-5321-b410-e37dc901cf28
DOI: 10.64898/2026.03.27.714813

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