Article

Gene Therapy With the N-Terminus of Junctophilin-2 Improves Heart Failure in Mice

2022-03-23

Abstract excerpt

Background: Transcriptional remodeling is known to contribute to heart failure (HF). Targeting stress-dependent gene expression mechanisms may represent a clinically relevant gene therapy option. We recently uncovered a salutary mechanism in the heart whereby JP2 (junctophilin-2), an essential component of the excitation-contraction coupling apparatus, is site-specifically cleaved and releases an N-terminal fragme...

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Literature Corpus work: 900db783-3e85-5463-862d-ddd30adbbacf
DOI: 10.1161/circresaha.121.320680

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