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Article

NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development

18 Jun 2020

Abstract excerpt

NADPH oxidases (NOX) are a major source of reactive oxygen species (ROS) production in the heart. ROS signaling regulates gene expression, cell proliferation, apoptosis, and migration. However, the role of NOX2 in embryonic heart development remains elusive. We hypothesized that deficiency of Nox2 disrupts endocardial to mesenchymal transition (EndMT) and results in congenital septal and valvular defects. Our...

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PMID: 32655758
DOI: 10.1155/2020/1679045

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